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Introduction to Buffer System || Regulation of pH || Acid Base Balance || Buffers in Biochemistry

Buffer system for the acid base balance and regulation of pH - This video is on the introduction to Acids, Bases, Buffers, physiological pH of blood and different types of extracellular buffer and intra cellular buffer which are first line of defense for the regulation of pH. Acids, Bases and buffers - 00:24 minutes Normal pH of the body fluids - 01:45 minutes Why maintenance of a pH is important - 02:28 minutes Fixed acids or Non volatile acids - 03:25 minutes Volatile acids - 03:50 minutes Metabolic Sources Of Bases - 04:05 minutes Mechanism for the regulation of pH - 04:40 minutes Buffering Capacity - 06:40 minutes pKa - 06:48 minutes Intracellular and Extracellular buffer - 07:42 minutes Bicarbonate Buffer system - 08:56 minutes Mechanism of Bicarbonate buffer - 09:43 minutes Phosphate buffer system - 12:47 minutes Mechanism of phosphate buffer - 13:08 minutes Protein buffer - 15:03 minutes Hemoglobin buffer - 16:12 minutes Mechanism of hemoglobin buffer - 17:14 minutes Chloride Shift - 18:28 minutes NEET PG Biochemistry MCQs - 21:03 minutes ACIDS, BASES AND BUFFERS An acid is defined as a substance that releases protons or hydrogen ions (H+), e.g. hydrochloric acid (HCI), carbonic acid (H2CO3). base is a substance that accepts protons or hydrogen ions, e.g. bicarbonate ion (HCO3–), and HPO4– – Buffer is a solution of weak acid and its corresponding salt which resists a change in pH when a small amount of acid or base is added to it. By buffering mechanism a strong acid (or base) is replaced by a weaker one. Normal pH Of The Body Fluids The normal pH of arterial blood is 7.4 pH of venous blood and interstitial fluids is about 7.35 The pH of blood is maintained within a remarkable constant level of 7.35 to 7.45. Regulatory Mechanisms to maintain normal Blood pH Buffer mechanism: First line of defense The respiratory mechanism: Second line of defense Renal mechanism: Third line of defense. Blood Buffer Buffer System Extracellular buffer Intracellularbuffer Bicarbonate NaHCO3/ H2CO3 KHCO3/H2CO3 Phosphate Na2HPO4/NaH2PO4 K2HPO4/KH2PO4 Protein Na Protein/H. Protein KHb/H.Hb KHbO2/H.HbO2 #biochemistrybasicsbydramit #pHregulation #buffersystem #acidbasebalance #NEETPG #NEETPGbiochemistry #USMLE