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Neurofibroma, Neurofibromatosis-1, and Low Grade MPNST

A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: https://kikoxp.com/posts/5084 (dermpath) & https://kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology). Learn about the different types of neurofibroma and their pathologic features in this video. I also discuss the scenarios where NF-1 should be considered, the features that are concerning for transformation into low grade malignant peripheral nerve sheath tumor (MPNST), and the immunohistochemical staining patterns of both neurofibromas and low grade MPNST*** (see note below). Entities/topics discussed (click timestamp to go to that part of the video): Solitary/Localized neurofibroma: 0:20 Schwann cell cytologic features: 4:25 Myxoid change in neurofibroma: 12:00 Plexiform neurofibroma & NF-1: 13:00 Diffuse neurofibroma: 17:35 Diffuse NF vs DFSP: 19:00 IHC in neurofibroma: 21:00 Degenerative atypia in neurofibroma vs Low grade MPNST: 38:00 IHC in low grade MPNST: 47:00 A list of my nerve sheath tumor videos: (links coming soon) - Schwannoma: - Malignant peripheral nerve sheath tumor (MPNST) - classic, epithelioid, & Triton: - Nerve sheath myxoma vs cellular neurothekeoma: - Neurofibroma, Neurofibromatosis-1, and Low Grade MPNST - Palisaded encapsulated neuroma: https://kikoxp.com/posts/3844 ***Please note that there is some debate about the term "low grade MPNST". A 2017 consensus statement suggested use of the term “atypical neurofibromatous neoplasms of uncertain biologic potential (ANNUBP)” for neurofibromas in the setting of NF1 that display at least 2 of these features: Nuclear atypia, loss of neurofibroma architecture, high cellularity, and/or mitotic activity greater than 1/50 HPF but less than 3/10 HPF. Nuclear atypia alone without these other features is thought to be merely a degenerative phenomenon that is not concerning for malignancy in this setting, as discussed in the video. For more info, read this paper: https://www.ncbi.nlm.nih.gov/pubmed/2... Please check out my Soft Tissue Pathology & Dermatopathology survival guide textbooks: http://bit.ly/2Te2haB ‬ This video is geared towards medical students, pathology or dermatology residents, or practicing pathologists or dermatologists. Of course, this video is for educational purposes only and is not formal medical advice or consultation. Presented by Jerad M. Gardner, MD. Please subscribe to my channel to be notified of new pathology teaching videos. Follow me on: Snapchat: JMGardnerMD Twitter: @JMGardnerMD Instagram: @JMGardnerMD Kiko: https://kikoxp.com/profile/jerad_gard... Facebook:   / jmgardnermd