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Peptide Easy Clean (PEC): A new turn in peptide purification

Purification of peptides is a challenging task, especially of diverse peptide libraries, due to their potentially broad distribution in physico-chemical properties. The Peptide Easy Clean (PEC) technology is universally applicable and enables the efficient and innovative manufacturing of new peptide based drug modalities. PEC increases the speed of peptide development since it can be used for parallel purifications, whereas high-pressure liquid chromatography (HPLC) only allows one-by-one processing of single samples. In addition, PEC is an orthogonal approach to chromatographic separation, facilitating the purification of difficult peptides; by using PEC methodology, aggregation or precipitation can be prevented and increased solubility in organic solvents is achieved. As a result of our continued collaboration, development of the linker molecules was achieved by Belyntic, with Bachem assisting as an industry partner for early testing on pharmaceutically relevant peptides. Our combined desire to innovate peptide manufacturing demonstrates that Bachem is the optimum partner for API development, closely supported by Belyntic for all PEC requirements. ------------------------------------------------------------------------------------------------ Webinar speakers: Robert Zitterbart, Ph.D. Co-Founder, Head of R&D at Belyntic GmbH The Peptide Easy Clean (PEC) Technology Gavin Noble, Ph.D. R&D Chemist at Bachem (UK) Ltd. Traceless parallel peptide purification by a first-in-class reductively cleavable linker system featuring a safety-release. ------------------------------------------------------------------------------------------------ Presentation resources: Animation of Belyntic's PEC peptide purification technology:    • Animation of Belyntic's PEC peptide p...   Parallel purification on a vacuum chamber:    • Belyntic PEC Explanation Video   ------------------------------------------------------------------------------------------------ About Bachem: Bachem is a leading, innovation-driven company specializing in the development and manufacture of peptides and oligonucleotides. With 50 years of experience and expertise Bachem provides products for research, clinical development and commercial application to pharmaceutical and biotechnology companies worldwide and offers a comprehensive range of services. Bachem operates internationally with headquarters in Switzerland and locations in Europe, the US and Asia. The company is listed on the SIX Swiss Exchange. For further information, see www.bachem.com. Learn more about our products and services at https://www.bachem.com/​ Bachem. Leading Partner in Tides