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Uronic Acid Pathway / Essential Pentosuria : Medical Biochemistry by Dr G Bhanu Prakash

📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:-   / drgbhanuprakash   📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/bhanuprakashdr 📌𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝗧𝗼 𝗠𝘆 𝗠𝗮𝗶𝗹𝗶𝗻𝗴 𝗟𝗶𝘀𝘁:- https://linktr.ee/DrGBhanuprakash Uronic Acid Pathway / Essential Pentosuria : Medical Biochemistry Overview • Part of carbohydrate metabolism • Involved in the conversion of sugars and uronic acids • Primarily functions in the liver Major Reactions • Formation of Glucuronic Acid: Uronic acids are converted into glucuronic acid, used in detoxification • Formation of Ascorbic Acid in Plants: Not applicable in humans • Formation of L-Gulonic Acid and L-Xylulose: Metabolism of glucose Importance • Detoxification: Conjugation with glucuronic acid increases water solubility of compounds • Excretion of Bilirubin: Glucuronic acid combines with bilirubin for excretion • Metabolism of Carbohydrates: Converts hexoses into pentoses, useful in various metabolic pathways Clinical Relevance • Essential Pentosuria: Linked to a deficiency in the pathway (explained below) • Drug Metabolism: Many drugs are conjugated with glucuronic acid for excretion Essential Pentosuria Overview • A rare, benign metabolic condition • Included in Garrod's tetrad (Pentosuria, Albinism, Cystinuria, Alkaptonuria) Cause • Deficiency of Xylitol Dehydrogenase: Enzyme involved in the conversion of L-xylulose Symptoms • Excretion of L-Xylulose in Urine: Leading to pentose sugars in urine Diagnosis • Benedict's Test Positive: Indicates reducing sugar in the urine • Bial's Test Positive: Specific for pentoses Alimentary Pentosuria • Occurs after consumption of large amounts of fruits rich in pentoses, like pears • Temporary and not linked to enzyme deficiency Treatment • Dietary Management: Limiting pentose intake • Monitoring: Regular check-ups to monitor urinary sugars #medicalbiochemistry #uronicacidpathway #essentialpentosuria #fmgevideos #fmge #rapidrevisionfmge #fmgejan2023 #mbbslectures #nationalexitexam #nationalexittest #neetpg #usmlepreparation #usmlestep1 #fmge #usmle #drgbhanuprakash #medicalstudents #medicalstudent #medicalcollege #neetpg2023 #usmleprep #usmlevideos #usmlestep1videos #medicalstudents #neetpgvideos #neetpgbiochemistry #medicalbiochem #biochemistryusmle