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A “key” discovery: Targeting DNA knots for cancer therapeutics | Caitlin Miron | TEDxQueensU

At least 85% of cancer cells take advantage of cellular processes controlled by unusual DNA “knots” known as guanine quadruplexes. Caitlin Miron, PhD Candidate in Chemistry at Queen’s University, explains how her serendipitous discovery of a chemical compound that binds strongly to these knots introduced her to an area of research that has widespread implications for anticancer therapeutics. Like other compounds previously developed in the field, this novel compound may be able to target guanine quadruplexes to prevent the cellular processes that contribute to cancer from occurring. Above all else, her experience has highlighted the importance of fundamental research in laying the groundwork that makes future journeys towards clinical trials possible. Caitlin Miron received her B.Sc.H. in Biochemistry in 2013 and is now completing a Ph.D. in Supramolecular and Biological Chemistry at Queen’s University under the supervision of Dr. Anne Petitjean. Caitlin’s research employs aspects of organic, inorganic, and analytical chemistry in order to design and develop dynamic molecular systems for biomedical applications. The opportunity to pursue research abroad under the supervision of Dr. Jean-Louis Mergny at the European Institute of Chemistry and Biology in Bordeaux, France led to her discovery of a novel molecule that stabilizes an unusual form of DNA which has implications for anticancer and antiviral applications. She was awarded the Mitacs Award for Outstanding Innovation (PhD) for this work. Her research has recently been highlighted in the media, including CTV, CBC, Global TV, The Kingston Whig-Standard, Hospital News, and BBC radio. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/tedx