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SPINDLE CELL UNKNOWNS | Bone & Soft Tissue Pathology Cases for Residents |

Digital Slides: - Case 1: https://kikoxp.com/posts/26465 - Case 2: https://kikoxp.com/posts/26467 - Case 3: https://kikoxp.com/posts/26469 --- Additional Cases: CASE 1: Schwannoma Variants: - Antoni A Predominant: https://kikoxp.com/slides/public/647a... - “Zebra Stripe” Verocay Bodies: https://kikoxp.com/slides/public/647a... - Cellular Features: https://kikoxp.com/slides/public/647a... - Extensive Hyalinization: https://kikoxp.com/slides/public/647a... - Extensive Myxoid Change: https://kikoxp.com/slides/public/647a... - Round Cell Features: https://kikoxp.com/slides/public/647a... CASE 2: - Hyalinizing spindle cell tumor with giant rosettes (LGFMS variant): https://kikoxp.com/slides/public/647e... - Myxofibrosarcoma, high-grade: https://kikoxp.com/slides/public/6482... CASE 3: - Post-Treatment Synovial Sarcoma: https://kikoxp.com/slides/public/647e... - Metastatic Synovial Sarcoma: https://kikoxp.com/slides/public/647e... - Metastatic Leiomyosarcoma: https://kikoxp.com/slides/public/647e... - MPNST/Malignant Triton Tumor: https://kikoxp.com/slides/public/647e... --- References: 1. Casadei GP, Scheithauer BW, Hirose T, Manfrini M, Van Houton C, Wood MB. Cellular schwannoma. A clinicopathologic, DNA flow cytometric, and proliferation marker study of 70 patients. Cancer. 1995;75(5):1109-1119. https://pubmed.ncbi.nlm.nih.gov/7850709 2. Schaefer IM, Hornick JL. SWI/SNF complex-deficient soft tissue neoplasms: An update. Semin Diagn Pathol. 2021;38(3):222-231. https://pubmed.ncbi.nlm.nih.gov/32646614 3. Zaborowski, M.; Vargas, A.C.; Pulvers, J.; Clarkson, A.; de Guzman, D.; Sioson, L.; Maclean, F.; Chou, A.; Gill, A.J. When used together SS18-SSX fusion-specific and SSX C-terminus immunohistochemistry are highly specific and sensitive for the diagnosis of synovial sarcoma and can replace FISH or molecular testing in most cases. Histopathology 2020, 77, 588–600. https://pubmed.ncbi.nlm.nih.gov/32559... --- For a complete list of all my educational posts & videos, check out my Pathology MEGA Index: https://kikoxp.com/posts/9579 You can also follow me on social media: - Twitter:   / melanocytemd   - Kiko: https://kikoxp.com/melanie_bourgeau1 - Instagram:   / melanocytemd   - Facebook: https://www.facebook.com/profile.php?... - Mastodon: http://med-mastodon.com/@melanocytemd --- Note: This video is for educational purposes only and is not formal medical advice or consultation.