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The mitochondrial theory of aging

Video Sponsor: Longevity.Technology - https://longevity.technology/?utm_sou... Mitochondria are the powerhouses of the cell involved in the generation of ATP, the cellular energy currency. However, during aging mitochondria accumulate mutations in their DNA, show reductions in bioenergetics and damage to their structure and integrity. Is this caused by reactive oxygen species (ROS)? Why is mitochondrial dysfunction a hallmark of aging? What can be done to prevent mitochondrial decline and improve biogenesis? Well, we will take a look at these questions in this video and the current mitochondrial theory of aging. TIMESTAMPS; Intro - 00:00 Mitochondria essentials - 00:30 The theories and evidence - 04:00 Treatment/Therapeutic potential? - 09:40 REFERENCES: (good review) Mammalian Mitochondria and Aging: https://doi.org/10.1016/j.cmet.2016.0... Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging Science, 309 (2005), pp. 481-484 (nice recent background to mitochondria and their cool biochemistry) - Stewart, J.B., Chinnery, P.F. Extreme heterogeneity of human mitochondrial DNA from organelles to populations. Nat Rev Genet 22, 106–118 (2021). https://doi.org/10.1038/s41576-020-00... Ultra-Sensitive Sequencing Reveals an..https://doi.org/10.1371/journal.pgen.... (you mean, you haven't read it already) The hallmarks of aging - https://doi.org/10.1016/j.cell.2013.0... Taking a “good” look at free radicals in the aging process - https://doi.org/10.1016/j.tcb.2011.06... Sun, N., Youle, R. J., & Finkel, T. (2016). The Mitochondrial Basis of Aging. Molecular cell, 61(5), 654–666. https://doi.org/10.1016/j.molcel.2016... Mok, B.Y., de Moraes, M.H., Zeng, J. et al. A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing. Nature 583, 631–637 (2020). https://doi.org/10.1038/s41586-020-24... Check out the latest video by ‪@LifespanNews‬ -    • Adult longevity, education, and racia...   Icons in intro; "https://www.freepik.com/free-photos-v..."Background vector created by freepik - www.freepik.com