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According to data from the 2019 CF Foundation Patient Registry, more than 50% of adults with cystic fibrosis experience sinus disease, in addition to more than 20% of adolescents with CF. Management of complications secondary to CF, such as sinus disease, is important for maintaining an individual's health and quality of life. Watch our sinus disease research webinar to hear Daniel Beswick, MD, from @UCLA, Anna Zemke, MD, PhD, from the @pittofficial, and Eliza Callard, an adult with CF, discuss this important topic including studies looking at the impact of highly effective modulators on sinus disease and sinus surgery outcomes. Originally recorded August 25, 2021. 0:00 | Research overview: sinus disease 33:17 | When does sinus disease first appear in people with cystic fibrosis? 34:31 | What is the effect of Trikafta on nasal polyps? 35:17 | What can people with CF do to preemptively minimize recurrence of sinus disease following surgery? 36:59 | Is there sinus research for people who are not on CFTR modulators? 38:15 | Are there any studies on sinus maintenance after Trikafta? 39:23 | Does Trikafta affect how frequently someone with CF may need sinus surgery? 40:12 | Is there any research into the use of probiotics in the sinuses? 41:40 | Is there a list of sinus treatments available for use as a guide in CF clinic? 42:49 | Is there any information on why the sinuses could become more plugged up after starting Trikafta? 44:10 | Are you sharing this data with ENTs globally? 45:47 | If sinus disease shows up in imaging for almost 100% of people with CF, why do only about half report symptoms? 49:03 | Is there any difference in the effectiveness of Trikafta on sinus disease for older vs. younger people with CF? 50:32 | To what degree does Trikafta slow the regrowth of nasal polyps? 51:07 | How are sinus issues correlated to lung issues in CF? 53:33 | Is there any research into how allergies might exacerbate sinus disease? 54:08 | Has iodine been looked at for use in sinus rinses? 54:55 | How do you properly clean nasal rinse bottles? 55:40 | Are there any studies linking CF carriers to advanced sinus disease? 56:54 | What future research are you excited about for sinus disease in CF?