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Your Microbiome Holds The Key To Curing Parkinson’s | Sarkis Mazmanian, PhD x Rich Roll

Rich sits down with Caltech microbiome research scientist & microbiology professor Dr. Sarkis Mazmanian to talk about how gut microbes influence neurological health, behavior, and conditions like Parkinson’s, autism, and depression. To read more about Dr. Mazmanian and peruse the full show notes, go here👉🏾https://bit.ly/richroll831 ​​This Episode Brought To You By... SQUARESPACE Get 10% OFF with code RichRoll 👉 https://bit.ly/squarespace2024 ON Use code RICHROLL10 at the checkout to get 10% OFF 👉 https://bit.ly/on2024 Check out all of the amazing discounts from our Sponsors 👉 https://bit.ly/rrpsponsors ✌🏼🌱 - Rich LISTEN / SUBSCRIBE TO THE PODCAST Apple Podcasts: http://bit.ly/rrpitunes Spotify: http://bit.ly/rrpspotify Google: http://bit.ly/rrpgooglepods Meal Planner: http://meals.richroll.com Voicing Change Book: http://richroll.com/vc Clips Channel:    / richrollpodcastclips   Newsletter: http://bit.ly/rollcallemail CONNECT WITH RICH ✩ Website - http://richroll.com​ ✩ Rich Roll Podcast - https://richroll.com/all-episodes/ ✩ Instagram -   / richroll   ✩ Twitter -   / richroll   ✩ Facebook -   / richrollfans   ✩ Strava - https://www.strava.com/athletes/14443... ✩ Memoir: Finding Ultra - https://www.richroll.com/shop/books/f... ✩ Meals - http://meals.richroll.com​ ✩ Cook - The Plantpower Way - https://www.richroll.com/shop/books/t... ✩ Italian! - The Plantpower Way: Italia - https://www.richroll.com/shop/books/t... ✩ Support -   / richroll   FILMED AND EDITED BY BLAKE CURTIS & DAN DRAKE https://www.blakecurtis.net/ https://www.dandrake333.com/ TIMESTAMPS 00:00:00 Intro 00:01:29 Introduction To Microbiome Research 00:04:23 Defining The Microbiome 00:06:11 Acceptance Of The Microbiome 00:07:53 Caltech As A Research Environment 00:09:04 The Gut-Brain Axis 00:13:52 Co-Evolution Of Microbiota And Humans 00:18:25 The Hygiene Hypothesis 00:20:45 Factors Affecting Microbiome Health 00:21:35 Building The Microbiome 00:22:26 Prenatal And Early Life Microbiome 00:24:39 Flexibility Of Adult Microbiome 00:26:27 Microbiome And Potential For Disease Transmission 00:29:49 Sponsor Break 00:30:55 Genetics And Microbiome Interaction 00:32:42 Environmental Triggers And Microbiome 00:35:55 Parkinson's And Gut Microbiome 00:41:55 Autism And The Microbiome 00:45:42 The Gut-Brain Axis And 4EPS 00:47:58 Oligodendrocyte Biology And Myelination 00:49:42 Parkinson's And Alpha-Synuclein Aggregation 00:52:55 Inhibition Of Bacterial Protein As Therapy 00:54:09 The Vagus Nerve And Parkinson's 00:57:01 Challenges In Translating Findings From Rodents To Humans 01:01:31 Sponsor Break 01:02:37 FDA's Perspective On Microbiome-Based Therapeutics 01:05:14 Direct Testing In Humans 01:06:27 The Effect Size Of Drugs 01:07:35 Research Landscape Of Neurological Disorders 01:08:36 Microbiome And Depression 01:11:06 Bi-Directional Communication Between Gut And Brain 01:13:29 Future Interventions For Microbiome-Based Therapies 01:15:56 Challenges And Potential Of Fecal Transplants 01:19:05 Complexity Of Microbiome Data 01:21:35 Dream Experiment For Studying Microbiome Impact 01:26:29 Influence Of Gut Microbiome On Food Cravings 01:29:12 The Microbiome And Sugar Cravings 01:30:17 Microbiome's Potential Impact On Addiction 01:32:10 Impact Of Diet On Microbiome And Cravings 01:35:50 The Microbiome's Influence On Sentience 01:38:57 Lifestyle Factors And Microbiome Health 01:40:30 The Role Of Fiber And Plant-Based Diets 01:43:48 Challenges Of Microbiome Testing And Interpretation 01:46:27 Future Of Microbiome Research And Healthcare 01:48:16 Big Pharma's Stance On Microbiome Research 01:50:04 Big Pharma's Business Model 01:51:54 Intellectual Property And Genetic Modification 01:53:10 Challenges Of Genetically Modified Microbes 01:54:54 Axial's Clinical Approach 01:58:37 Parkinson's Intervention Development 02:01:34 Microbiology Renaissance 02:02:42 Educational Resources And Skepticism 02:04:12 Closing Remarks And Credits * * * * * NEW TO RICH? Hi I'm Rich Roll. I'm a vegan ultra-endurance athlete, author, podcaster, public speaker & wellness evangelist. But mainly I'm a dad of four. If you want to know more, visit my website or check out these two the NY Times articles: http://bit.ly/otillonyt http://bit.ly/vegansglam I LOVE MAIL! SEND IT HERE: 2630 Conejo Spectrum St. Thousand Oaks, CA 91320 #richroll #richrollpodcast