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Insulin Activated Glycogenesis. How Glucose is Stored as Glycogen. PP1 and GSK3 Pathway.

This lecture starts by explaining how and why glucose is converted to glucose-6-phosphate. It then discusses how glucose-6-phosphate can be added to glycogen. Next it explains how Insulin activates protein phosphatase 1 (PP1) and inhibits GSK3. It then explains how simultaneous activation of PP1 and inhibition of GSK3 influences glycogen synthase. It finishes by discussing the influence PP1 and exercise (physical activity) influence glycogen phosphorylase. 0:00 Glucose to Glucose-6-Phosphate 2:54 Glucose-6-phosphate to Glycogen 7:19 Insulin Activation of Protein Phosphatase 1 (PP1) 10:02 Insulin Inhibition of GSK3 14:54 PP1 activation and GSK3 Inhibition Simultaneously 19:54 PP1 Inhibition of Glycogen Phosphorylase 25:08 Exercise Activation of Glycogen Phosphorylase