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Epitope Mapping in Antibody Therapeutics and Vaccine Development: The Evolving Landscape

Understanding the precise binding sites of antibodies on their target antigens can significantly advance the discovery and development of new therapeutics and vaccines, providing critical insights into mechanisms of action and protection. While there are numerous approaches for epitope mapping, comprehensive, high-throughput mutagenesis has emerged as a leading technique for both conformational and linear epitopes that couples high-resolution results with the speed that the biopharmaceutical industry demands. Epitopes have also become paramount for intellectual property considerations, such as patentability or freedom to operate evaluations. Both patents and regulatory submissions have been strengthened by the knowledge of specific binding site information. However, recent changes to intellectual property and regulatory laws surrounding epitope patentability and biosimilars necessitate adjusting antibody IP strategies. Our panelists for this webinar will discuss the importance of epitope mapping in drug and vaccine discovery from the scientific as well as the legal perspectives.