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SETI Talks archive: http://seti.org/talks Laser ablation (LA) with optical (LIBS) or mass (ICP-MS) detection is an excellent technology for direct sample (solid, liquid, gas) analysis. Benefits of laser ablation include no sample preparation, no consumables, every sample, real-time analysis, standoff (LIBS) measurements, and more. Knowledge of ablation processes, reliable system components, and development of methods has led to excellent performance metrics (accuracy and precision) of this technology. In general, LIBS provides ppm sensitivity for elemental analysis and molecular characterization based on database libraries and chemometrics. LA-ICP-MS provides ppb elemental analysis and isotopic ratios. New research shows the ability to perform isotope measurements in the laser plasma at atmospheric pressure. Dr. Russo will present a general overview of the underlying mechanisms for laser ablation, attributes of LIBS and LA-ICP-MS, the ability to measure isotopic signatures in laser ablation plasmas at atmospheric pressure, and the commercialization of analytical instruments for such measurements.