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Antibiotic Resistance: How Humans Ruined Miracle Drugs

Antibiotic resistance is possibly the biggest existential threat to humanity. What were the causes, how does it work, and what do we do about it? ☠️NONE OF THE INFORMATION IN THIS VIDEO SHOULD BE USED AS MEDICAL ADVICE OR OPINION. IT IS FOR GENERAL EDUCATION AND ENTERTAINMENT☠️ 🔗 L I N K S 🔗 📱Instagram:   / patkellyteaches   💰Patreon:   / corporis   📚My favorite books https://docs.google.com/document/d/1w... 🔑 P A T R O N S 🔑 Joanne K Sal F. Ansel K Anton Brandon K Pranav M Paul Brendan P Dane M Kristoffer R Jakub V Joe B Karly N Mindi F Drake W Kathy K Mike W Hyeon-Seo Jacob S. Robin B Robb W Sarah B Carl Dontae W Karen S Michael R Brian H Jonathan G Brian T Thelma S Silverstar Brian B Michael G Zoe C 📜 S O U R C E S 📜 Annotated script found here:   / antibiotic-video-95558251   [Affiliate links] I get a commission if you decide to buy it through this link. Miracle Cure, the Creation of Antibiotics by William Rosen https://www.amazon.com/Miracle-Cure-C... Big Chicken by Maryn McKenna Antibiotic Discovery and Resistance: The Chase and the Race (2022) https://pubmed.ncbi.nlm.nih.gov/35203... THIS ONE WAS GREAT Antibiotic resistance in microbes: History, mechanisms, therapeutic strategies and future prospects (2021) https://www.sciencedirect.com/science... The antibiotic resistance crisis, with a focus on the United States (2017) https://www.nature.com/articles/ja201730 Origins and Evolution of Antibiotic Resistance (2010) https://www.ncbi.nlm.nih.gov/pmc/arti... WHO Fact Sheet https://www.who.int/news-room/fact-sh... FDA Fact Sheet https://www.fda.gov/emergency-prepare... CDC Fact Sheet https://www.cdc.gov/drugresistance/ab... CDC 2019 AMR report https://www.cdc.gov/drugresistance/bi... The evolving response to antibiotic resistance (1945–2018) https://www.nature.com/articles/s4159... Chain & Abraham Penicillinase (1940) https://www.nature.com/articles/146837a0 1945 Fleming Nobel Prize speech https://www.nobelprize.org/uploads/20... Ampicillin https://www.ncbi.nlm.nih.gov/pmc/arti... Methicillin trial in BMJ (1960) https://europepmc.org/backend/ptpmcre... Carbapanems https://www.ncbi.nlm.nih.gov/pmc/arti... Evolution of B-lactamase inhibitors (1991) https://www.jstor.org/stable/pdf/4456... Animal Protein Factor by Jukes et al (1949) CC BY 4.0 DEED https://www.sciencedirect.com/science... ON THE MECHANISM OF THE DEVELOPMENT OF MULTIPLE DRUG-RESISTANT CLONES OF SHIGELLA (1960) https://onlinelibrary.wiley.com/doi/p... Swann Report (1969) https://wellcomecollection.org/works/... A Review of Antibiotic Use in Food Animals: Perspective, Policy, and Potential (2012) https://journals.sagepub.com/doi/pdf/... Pharming animals: a global history of antibiotics in food production https://www.nature.com/articles/s4159... Staphylococcal Infection in Meat Animals and Meat Workers, Ravenholt (1961) https://www.jstor.org/stable/4591310 Study on genetic engineering of Acremonium chrysogenum, the cephalosporin C producer (2016) https://www.ncbi.nlm.nih.gov/pmc/arti... A Glimpse of the early history of the cephalosporins (1979) https://www.jstor.org/stable/pdf/4452... Celbenin resistant Staph (original MRSA paper - 1961) https://www.ncbi.nlm.nih.gov/pmc/arti... MRSA in Boston City Hospital (1968) https://www.nejm.org/doi/10.1056/NEJM... Five decades of MRSA https://www.thelancet.com/journals/la... Carbapnems: Past, Present, and Future https://www.ncbi.nlm.nih.gov/pmc/arti... Thienamycin to Imipenem (1983) https://academic.oup.com/jac/article-... FDA GFIs https://www.fda.gov/animal-veterinary... GDI 213 FDA Document https://www.fda.gov/media/83488/download Use of Ichip for High-Throughput In Situ Cultivation of “Uncultivable” Microbial Species (2010) https://www.ncbi.nlm.nih.gov/pmc/arti... Discovery of teixobaxtin (2015) https://www.nature.com/articles/natur... 💻 C O N T A C T 💻 If you’d like to sponsor a video or have other business inquiries: patkellyteaches [at] gmail.com ⌛T I M E S T A M P S ⌛ 0:00 Intro 0:58 Biology of Antibiotic Resistance 5:51 Human Use 16:24 Agriculture 26:41 Solutions