Скачать с ютуб Sven Malik, Senior Application Specialist, Bruker Daltonics SPR в хорошем качестве

Sven Malik, Senior Application Specialist, Bruker Daltonics SPR

SLAS2022 On-Demand: Next level of high throughput SPR screening: 10,000 compound screen enabled by Bruker SPR Even as researchers leverage a host of new technologies to pervade the design of libraries and screening workflows for a detailed candidate selection, it has remained a challenge to generate real-time, direct-binding results at scale despite the confidence and insights that they provide. The Bruker SPR-32 Pro platform was designed to empower researchers with the sensitivity and multiplexing capabilities needed to support and expedite these evolving discovery cycles for both fragments and biologics. This talk highlights the key points to enable fragment screens at a new throughput levels. An entire library of 10,000 compounds (28x384-well plates) was comprehensively screened for general-binding over 5-6 days against three targets and a reference per channel. Plate loading was fully automated using the Orbitor plate changer (Thermo Scientific).