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Chronic Myeloid Leukemia (CML) | Pathogenesis, Symptoms and Treatment

Lesson on Chronic Myeloid Leukemia (CML): Pathogenesis, Symptoms and Treatment. Chronic Myeloid (or Myelogenous) Leukemia (CML) is one type of leukemia, which is a blood cancer with high levels of white blood cells. CML is a leukemia with proliferation of mature neutrophils (PMNs), as evidenced by white blood cells with large nuclei on a blood smear or peripheral blood film. CML often presents asymptomatically, but can progress to having characteristic signs and symptoms of splenomegaly, constitutional symptoms, and lower sternum tenderness. Pathogenesis of CML is due to the Philadelphia Chromosome, which is a product of translocation of chromosomes 9 and 22, leading to a new fusion gene and protein product. This new protein (BCR-ABL) is an activated tyrosine kinase, which leads to activation of cellular survival and proliferation pathways. Treatment of CML involves a drug known as imatinib, which has been designed to specifically target the BCR-ABL fusion protein. I hope you find this video helpful! If you do, please like and subscribe for more lessons like this one :) Please also check out some of my other hematology videos! JJ Subscribe for more free medical lessons    / @jjmedicine   ------------------------------------------------------------------------------------------------------------- For books and more information on these topics https://www.amazon.com/shop/jjmedicine Support future lessons (and get other cool stuff) ➜   / jjmedicine   Follow me on Twitter! ➜   / jj_medicine   Come join me on Facebook! ➜   / jj-medicine-100642648161192   Start your own website with BlueHost ➜ https://www.bluehost.com/track/jjmedi... Check out the best tool to help grow your YouTube channel (it’s helped me!) https://www.tubebuddy.com/jjmedicine ------------------------------------------------------------------------------------------------------------- Check out some of my other lessons. Medical Terminology - The Basics - Lesson 1:    • Medical Terminology - The Basics - Le...   Fatty Acid Synthesis Pathway:    • Fatty Acid Synthesis Pathway: Overvie...   Wnt/B Catenin Signaling Pathway:    • Wnt/β-Catenin Signaling Pathway | Ove...   Upper vs. Lower Motor Neuron Lesions:    • Upper and Lower Motor Neuron Lesions ...   Lesson on the Purine Synthesis and Salvage Pathway:    • Purine Synthesis and Salvage Pathway   Gastrulation | Formation of Germ Layers:    • Gastrulation | Formation of Germ Laye...   Introductory lesson on Autophagy (Macroautophagy):    • Autophagy | Macroautophagy & Importan...   Infectious Disease Playlist    • Infectious Diseases   Dermatology Playlist    • Dermatology   Pharmacology Playlist    • Pharmacology   Hematology Playlist    • Hematology   Rheumatology Playlist    • Rheumatology   Endocrinology Playlist    • Endocrinology   Nephrology Playlist    • Nephrology   ---------------------------------------------------------------------------------------------------- **MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal. Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition. ---------------------------------------------------------------------------------------------------- Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know. I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :) Thanks for watching! If you found this video helpful, please like and subscribe! JJ