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Prof Jack Cuzick speaks to ecancer at the 2019 San Antonio Breast Cancer Symposium about the preventative effects of anastrozole in post-menopausal, high-risk women. He explains the rationale behind this study, which has achieved a 60 percent reduction of breast cancer incidence in the first five years and an additional 36 percent after every subsequent year. Prof Cuzick also notes that this long-term follow up shows the effectiveness of anastrozole over tamoxifen. He also discusses how patients were stratified as "high-risk", associated adverse effects and the possibility of investigating mortality in the future. Sign up to ecancer for free to receive tailored email alerts for more videos like this. ecancer.org/account/register.php