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Vitamin D reduces autoimmune disease

Come on government, change the out dated guidelines. John's text books, free downloads, http://159.69.48.3/ Vitamin D regulates a wide array of genes involved in inflammation and immunity, inconsistently associated with reduced risk of several autoimmune diseases in observational studies Active form of vitamin D regulates genes, inflammation, acquired and innate immune responses Dietary marine derived long chain omega 3 fatty acids decrease systemic inflammation in some autoimmune diseases Evidence is needed on whether omega 3 fatty acids lower the risk of developing autoimmune disease Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial https://www.bmj.com/content/376/bmj-2... To investigate whether vitamin D and marine derived long chain omega 3 fatty acids reduce autoimmune disease risk. Vitamin D and omega 3 trial (VITAL), a nationwide (US), randomized, double blind, placebo controlled trial N = 25, 871 consisting of, 12, 786 men ≥50 13, 085 women ≥55 18,046 non- Hispanic white 5,106 black 2,152 as other racial and ethnic groups Mean age was 67.1 INTERVENTIONS Vitamin D (2000 IU/day) or placebo Omega 3 fatty acids (1000 mg/day) or placebo Participants self-reported all incident autoimmune diseases from baseline to a median of 5.3 years, these diseases were confirmed by medical record review In the vitamin D arm Treatment group 123 developed an autoimmune disease Placebo group 155 developed an autoimmune disease Hazard ratio 0.78 P = 0.05 In the omega 3 fatty acids arm Treatment group 130 developed an autoimmune disease Placebo group 148 developed an autoimmune disease P=0.19 CONCLUSIONS Vitamin D supplementation for five years with or without omega 3 fatty acids, reduced autoimmune disease by 22% Omega 3 fatty acid supplementation with or without vitamin D, reduced the autoimmune disease rate by 15% (not statistically significant) The clinical importance of this trial is high because these are well tolerated, non-toxic supplements, and other effective treatments to reduce the incidence of autoimmune diseases are lacking Autoimmune diseases Rheumatoid arthritis Polymyalgia rheumatica Hashimoto’s thyroiditis, too little thyroid hormone) Psoriasis Type 1 diabetes mellitus Multiple sclerosis Lupus Inflammatory bowel disease (Crohn’s Ulcerative colitis) Addison’s (too little of cortisol) Grave’s (too much thyroid hormone), Myasthenia gravis Pernicious anemia Autoimmune vasculitis Celiac disease (gluten protein from grains) Inflammatory autoimmune response to self-tissues Third leading cause of morbidity in the industrialized world Chronic conditions Increasing prevalence with age Lack of effective treatments More about the VITAL RCT https://clinicaltrials.gov/ct2/show/N... VITamin D and OmegA-3 TriaL (VITAL) A randomized clinical trial, US based N = 25,871 Investigating Daily dietary supplements of vitamin D3 (2000 IU), or omega-3 fatty acids (Omacor® fish oil, 1 gram), reduces the risk of developing, cancer heart disease stroke, in people with no specific history 5-year intervention phase (study pill-taking, median 5.3 years) has ended post-intervention observational follow-up, ongoing