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The genetics and epidemiology of Lynch syndrome

Heather Hampel, MS, City of Hope, Duarte, CA, gives a summary of Lynch syndrome, the most common form of inherited colorectal cancer and endometrial cancer. The condition also increases the risk of developing other cancers such as biliary and pancreatic cancer, and whilst preventable, is heavily underdiagnosed. Patients who have Lynch syndrome will have annual colonoscopies from their 20s/30s or have an elective hysterectomy. Tumors additionally tend to be microsatellite instability (MSI) high, which can benefit from immune checkpoint inhibitor therapy. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Gastrointestinal Cancers (GI) Symposium in San Francisco, CA. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved. View our new feature exploring genomic biomarkers in metastatic colorectal cancer here: https://bit.ly/3DcSevZ