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At the new Design Lab at UC San Diego, design is a way of thinking, understanding people real, fundamental needs, and designing systems that fulfill those needs in an understandable, enjoyable manner. Does it matter? Yes. Medical error is the second largest cause of death in healthcare (alongside cancer and heart attack). And most of this error is caused by poor design of instruments, devices, and procedures. Autonomous cars promise to save lives, but how do pedestrians interact when the cars have no drivers? In this lecture, I describe some of the problems we are studying, including healthcare and autonomous automobiles, showing how we approach these issues. We practice a philosophy of people-centered design where we start by observation, then progress to deep analysis of the underlying issues, to rapid prototypes (in hours), testing, and continual iteration. Engineers and computer scientists need to understand these principles. Engineers often make the mistake of being far too logical. What do I mean? Come to the discussion.