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Thanks to the University of Minnesota for sponsoring this video! http://twin-cities.umn.edu/ The same enzyme that used to save us is now killing us because the body reactions it catalyzes now cause more harm than good. Thanks also to our Patreon patrons / minuteearth and our YouTube members. ___________________________________________ To learn more, start your googling with these keywords: Cyclooxygenase: An enzyme responsible for the production of thromboxane and prostaglandins. Thromboxane: A lipid that acts as a platelet aggregator. Platelets: Special non-nucleic blood cells that clump together to cause blood clots. Prostaglandins: A lipid that causes vasodilation and inflammation. Aspirin: A form of acetylsalicylic acid that acts as an NSAID. NSAIDs: Non-steroidal Anti-Inflammatory Drugs that inhibit COX, and thus inflammation and clotting. ___________________________________________ Subscribe to MinuteEarth on YouTube: http://goo.gl/EpIDGd Support us on Patreon: https://goo.gl/ZVgLQZ And visit our website: https://www.minuteearth.com/ Say hello on Facebook: http://goo.gl/FpAvo6 And Twitter: http://goo.gl/Y1aWVC And download our videos on itunes: https://goo.gl/sfwS6n ___________________________________________ Credits: Script Writer and Narrator: David Goldenberg Video Illustrators: Ever Salazar and Sarah Berman Video Directors: David Goldenberg and Ever Salazar With Contributions From: Henry Reich, Alex Reich, Kate Yoshida, Ever Salazar, Peter Reich and Julián Gómez Music by: Nathaniel Schroeder: / drschroeder ___________________________________________ References: Fitzpatrick, F. (2004). Cyclooxygenase Enzymes: Regulation and Function.Current Pharmaceutical Design. 10:577-588. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/1.... Dubois, R., Abramson, S., Crofford, L., Gupta, R., Simon, L., Van De Putte, L., Lipsky, P. (1998). Cyclooxygenase in biology and disease. The FASEB Journal 212(12):1063-73. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/9.... Havird, J., Kocot, K., Brannock, P., Cannon, J., Waits, D., Weese, D., Santos, S., Halanych, K. (2015). Reconstruction of cyclooxygenase evolution in animals suggests variable, lineage-specific duplications, and homologs with low sequence identity. 80(3-4):193-208. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/2.... Ricciotti, E. and FitzGerald, G. (2011).Prostaglandins and Inflammation. ATVB In Focs. 31(5): 986–1000. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/arti.... Rao, P., and Knaus, E. (2008). Evolution of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Cyclooxygenase (COX) Inhibition and Beyond. Journal of Pharmaceutical Science. 11 (2): 81-110. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/1.... Van't Hof, J., Duval, S., Misialek, J., Oldenburg, N., Jones, C., Eder, M., Luepker, R. (2019). Aspirin Use for Cardiovascular Disease Prevention in an African American Population: Prevalence and Associations with Health Behavior Beliefs. Journal of Community Health. 44(3):561-568. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/3.... Leupker, R. (2019). Personal Communication. Minnesota Heart Health Program. University of Minnesota. Chipman, J. (2019). Personal Communication. Department of Surgery. University of Minnesota.