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Brain Atrophy in Multiple Sclerosis Explained by Neurologist

In multiple sclerosis, the rate of brain atrophy (shrinkage) is accelerated compared to normal aging. How fast is the rate of atrophy? Can disease modifying therapies stop it? What about HSCT? Related Videos: Smouldering Multiple Sclerosis:    • Smouldering Multiple Sclerosis   Stem Cell Transplant for Multiple Sclerosis (aHSCT):    • Stem Cell Transplant for Multiple Scl...   Selected Sources: Brain atrophy in multiple sclerosis: mechanisms, clinical relevance and treatment options: https://autoimmunhighlights.biomedcen... Cortical atrophy is relevant in multiple sclerosis at clinical onset: https://link.springer.com/article/10.... Brain atrophy and disability progression in multiple sclerosis patients: a 10-year follow-up study: https://jnnp.bmj.com/content/85/10/1109 The effect of disease-modifying therapies on brain atrophy in patients with clinically isolated syndrome: a systematic review and meta-analysis: https://journals.sagepub.com/doi/10.1... MAGNIMS consensus recommendations on the use of brain and spinal cord atrophy measures in clinical practice: https://www.nature.com/articles/s4158... Table 1 Brain atrophy outcomes in pivotal trials of approved disease-modifying drugs: https://www.nature.com/articles/s4158... Five years of ocrelizumab in relapsing multiple sclerosis OPERA studies open-label extension: https://n.neurology.org/content/95/13... Reduced brain atrophy rates are associated with lower risk of disability progression in patients with relapsing multiple sclerosis treated with cladribine tablets: https://journals.sagepub.com/doi/10.1... Early brain pseudoatrophy while on natalizumab therapy is due to white matter volume changes: https://journals.sagepub.com/doi/10.1... Impact of autologous haematopoietic stem cell transplantation on disability and brain atrophy in secondary progressive multiple sclerosis: https://journals.sagepub.com/doi/10.1... Intermediate-Intensity Autologous Hematopoietic Stem Cell Transplantation Reduces Serum Neurofilament Light Chains and Brain Atrophy in Aggressive Multiple Sclerosis: https://www.ncbi.nlm.nih.gov/pmc/arti... Comment or ask questions below! I would be happy to answer! Subscribe on YouTube for more videos every Wednesday! Make video requests in the comments section! Check out my book “Resilience in the Face of Multiple Sclerosis” FREE on Amazon: https://amazon.com/dp/B07WP7H5LK It's about 5 people with MS who live incredible lives, the science and psychology of resilience, mindfulness, and ho’oponopono. Paperback priced to generate $0 royalty. Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research. Follow me on twitter:   / brandon_beaber   Music: INNER GRACE - Copyright 2018 Wilton Vought Source: Really Really Free Music Link:    • Видео   T he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.