Скачать с ютуб Claire Foldi PsychedelX 2024 Keynote - Targeting cognitive function to treat anorexia nervosa в хорошем качестве

Claire Foldi PsychedelX 2024 Keynote - Targeting cognitive function to treat anorexia nervosa

PsychedelX 2024 Day 2: STEM Keynote Address Claire Foldi, PhD Targeting cognitive function to treat anorexia nervosa – insights into the effects of psilocybin in animal models Anorexia nervosa (AN) has one of the highest mortality rates of any psychiatric disorder and less than 50% of patients ever recover. Despite this, there are currently no effective medicinal treatments. Psilocybin is currently being explored as a novel therapeutic for AN, and is proposed to act by “breaking down” inflexible patterns of thought and behaviour. To investigate the biological determinants of pathological weight loss, we use a well-established rodent model called activity-based anorexia (ABA), in which unlimited access to a running wheel paired with time-limited access to food precipitates voluntary hyperactivity, voluntary starvation, and rapid body weight loss. In this presentation, I will describe studies investigating the effects of psilocybin on anorectic behaviour in ABA rats and on different cognitive behaviours using novel open-source home-cage operant testing devices (the Feeding Experimental Device 3; FED3) across a range of tasks. I will show how these effects are mediated by signalling through specific serotonin receptor subtypes and highlight a need to understand the mechanistic bases of psychedelics beyond a focus on serotonin 2A receptor function. Dr Claire Foldi leads a program of research focused on the neurobiological underpinnings of anorexia nervosa, including the role of specific neural circuits and cognitive behaviours using the activity-based anorexia (ABA) rat model. The Foldi Lab is also investigating how psilocybin acts in the brain to modify behaviour in order to gain insight into its therapeutic potential for anorexia nervosa with funding from the National Health and Medical Research Council (NHMRC) of Australia. Dr Foldi co-leads the Workforce Development stream of the Australian Eating Disorders Research and Translation Centre (AEDRTC), through which she has developed and implemented strategies to expand the capacity and capability of the eating disorders workforce, in line with the principles of genuine co-design and co-production of research.