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Fasting, Autophagy and Cell Repair - with Dr. Satchin Panda | The Proof EP 221

In Episode 221, I sit down with Dr Satchin Panda to continue The Proof’s conversation on time restricted eating. 👇 Visit The Proof website for supporting studies and the full shownotes 👇 https://theproof.com/podcast/ Time-restricted eating (TRE) has caused a stir on social media in recent years. Many studies on TRE are misrepresented online, with people drawing absolute conclusions that often don’t consider all the data. Dr Panda joins me in this episode to look further into TRE, with a focus on circadian rhythm. Satchidananda (Satchin) Panda, PhD is a professor at The Salk Institute. His lab studies how circadian rhythm in metabolism is an integral part of metabolic health and longevity. He is currently investigating how temporal regulation of metabolism can prevent or reverse chronic diseases and increase lifespan in humans, building upon his preclinical animal trials. Dr Panda is very well versed in all things metabolism and circadian rhythm and brings more clarity to today’s conversation about TRE. In this episode, we have a detailed discussion about circadian rhythms, circadian disruption, and health impacts. We discuss TRE in the context of circadian biology, blood glucose, and calorie restriction. Dr Panda also offers his advice on the optimal TRE lifestyle. Specifically, we cover: 0:00 Intro 2:20 Circadian Rhythms 9:35 Why Circadian Disruption is a Problem 15:29 Dr. Panda’s Early Research 21:05 What Causes Sleep Deprivation 26:07 Disease & Circadian Disruption 28:59 Light Exposure 35:19 Time Restricted Eating 43:57 Optimal Eating Window 56:07 Impact on Blood Glucose 1:03:35 TRE vs Calorie Restriction 1:24:12 Addressing Concerns 1:26:52 Is Fasting Safe for Everyone? 1:35:31 Extended Fasts 1:39:00 Big Picture 1:43:14 Outro There are plenty of actionable takeaways in this week’s episode. Dr Panda’s research is certainly opening us up to greater clarity on this topic, and his educated insights this week offer practical and useful tips that will help clear the confusion. Connect with Dr Satchin Panda: • Twitter:   / satchinpanda   • His peer reviewed papers on Google Scholar: https://www.salk.edu/scientist/satchi... • His book: The Circadian Code: https://www.bookdepository.com/The-Ci... • The Circadian Diabetes Code: https://www.bookdepository.com/The-Ci... • Dr Panda’s app, myCircadianClock: https://mycircadianclock.org/ The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit http://theproof.com/friends Enjoy, friends. Simon Additional resources, supporting studies: • Dr Satchin's Peer Reviewed Papers: https://scholar.google.com/citations?... • Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes [PMID: 29754952] https://pubmed.ncbi.nlm.nih.gov/29754... ==== Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit https://theproof.com/friends/. • The Proof with Simon Hill - https://theproof.com/podcast/ • Book: The Proof is in the Plants - https://theproof.com/book/ • Apple Podcast - https://podcasts.apple.com/gb/podcast... • Spotify - https://open.spotify.com/show/7bAIJCV... • Instagram -   / theproof   • Twitter -   / theproof   • Facebook -   / theproofwithsimonhill   • Two week meal plan - https://theproof.com/mealplan/ • Plant Performance - https://theproof.com/plant-performance/ • Use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. #theproofpodcast #simonhill #drsatchinpanda #timerestrictedeating #fasting #nutrition #health