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Untangler of Knots: The Amazing Topoisomerase Molecular Machine

Topoisomerase II is an extremely important enzyme in your cells that is designed to untangle knots and supercoils in DNA strands that arise during replication and transcription. It does this by grabbing two tangled DNA segments, holding one steady while it breaks the other segment in two, and then passing the first segment through the break. The second segment is then reconnected, and the two DNA segments are released, having been successfully untangled. Without topoisomerases, chromosomes would become an impossible mess, making DNA replication, transcription, and cell duplication impossible. The carefully orchestrated untangling activity of topoisomerase II doesn’t happen by accident. This enzyme is a molecular machine that only works because its amino acid sequence is highly specified to provide a special shape and structure necessary for its function. In other words, topoisomerase enzymes contain high levels of complex and specified information—a hallmark of intelligent design. ============================ The Discovery Science News Channel is the official Youtube channel of Discovery Institute's Center for Science & Culture. The CSC is the institutional hub for scientists, educators, and inquiring minds who think that nature supplies compelling evidence of intelligent design. The CSC supports research, sponsors educational programs, defends free speech, and produce articles, books, and multimedia content. For more information visit https://www.discovery.org/id/ http://www.evolutionnews.org/ http://www.intelligentdesign.org/ Follow us on Facebook and Twitter: Twitter: @discoverycsc Facebook:   / discoverycsc   Visit other Youtube channels connected to the Center for Science & Culture Discovery Institute:    / discoveryinstitute   Dr. Stephen C. Meyer:    / drstephenmeyer   The Magician's Twin - CS Lewis & Evolution:    / cslewisweb   Darwin's Heretic - Alfred Russel Wallace:    / alfredrwallaceid