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2023 Dupuytren Disease and Research for a Cure

This recording is Dr. Eaton's presentation for the Dupuytren Research Group on Saturday, June 3, 2023 in New York City. A very special thanks to the Hospital for Special Surgery in New York City for supplying the event facility and presentation recording. For privacy, post-presentation discussions were not recorded. See below for summaries of some of the topics discussed. What is Dupuytren? A chronic medical disease that affects the hands and sometimes elsewhere. It causes lumps in the palm and sometimes bent fingers. Sometimes it causes bumps on the back of finger knuckles (“knuckle pads”). Sometimes it causes lumps on the instep of the foot (“Ledderhose disease”). Named after the 1800s French surgeon who invented surgery for it. Who is most likely to develop Dupuytren? Seniors with European ancestry and with affected family members. Some additional risks from injury, diabetes, smoking, drinking, and heavy hand work. How common is it? 10 million Americans have it, most with the mild version and no bent fingers. What is the timeline? One in five people will develop bent fingers within ten years of diagnosis. What can slow down or stop fingers from bending over the long term? No current treatment has been statistically proven to prevent finger bending. How do Doctors treat it? The only effective treatments are procedures to unbend fingers. Open surgery (fasciectomy) removes affected tissue inside the palm. Minimally invasive (Xiaflex; needle release) lengthens affected tissue. Knuckle pads and Ledderhose don’t contract and rarely need treatment. What is the biggest problem with Dupuytren disease? Recurrence after treatment is the critical unsolved problem. What is diathesis? A way to guess the risk of recurrence after surgery using three factors: Relatives with Dupuytren, Diagnosis before age 50, and Ledderhose. It’s not clear that it is reliable. Recent studies suggest it isn’t. It doesn’t predict any more rapid progression in those with vs. those without. Why aren’t medicines proven to prevent progression and recurrence? Preventive medical research is impractical if the only test is finger angles. How can we find a cure? We need a blood biomarker test to develop and test preventive treatments. We need significant funding for research to make a blood biomarker test. Who is doing research for a cure? Only the Dupuytren Research Group is conducting large-scale dynamic biomarker discovery research. How can I help the mission of the Dupuytren Research Group? Enroll in research: https://DupStudy.com Share your expertise in research, nonprofit management, and fundraising Spread the word about Dupuytren and DRG research Support DRG research through charitable giving Contact the DRG to discuss more: [email protected]