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During ResearchCon 2024, Daniela Cortez and Charles Farrell, two adults with cystic fibrosis, Meghana Sathe, MD, a pediatric clinician, and David Assis, MD, an adult clinician, discuss liver disease and CF. They share their experiences and expertise around chronic liver disease, necessary screenings, maintaining liver health, how CFTR modulators impact the liver, preparing for a liver transplant, and life post-liver transplant. Originally recorded May 1, 2024. 0:00:00 | Understanding the Complexities of Liver Disease and Cystic Fibrosis 0:04:35 | The liver and its functions 0:07:15 | Anatomy of the liver 0:09:35 | Where is CFTR in the liver and what does it do? 0:11:30 | How can CFTR defects cause liver disease? 0:16:15 | What are CF Hepatobiliary Involvement (CFHBI) and Advanced CF Liver Disease (ACFLD)? 0:19:48 | What are the manifestations of decompensated ACFLD? 0:32:00 | New CFHBI and ACFLD screening guidelines 0:32:40 | How do we screen for CFHBI and ACFLD? 0:35:45 | How do we evaluate for CFHBI and ACFLD? 0:38:09 | Assessment of liver fibrosis 0:42:00 | Management of CFHBI 0:47:29 | Management of ACFLD 0:52:55 | CFTR modulators and the liver 0:58:00 | How to live a fulfilling life despite CF liver disease? 1:02:45 | Liver transplantation in CF 1:03:43 | Liver vs. Lung-liver transplant in CF 1:04:40 | How, why, when to get on the liver transplant list? 1:05:38 | Life after liver transplant