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The Function of Serotonin | Robin Carhart-Harris and David Nutt Adversity Hypothesis

The function of serotonin in the brain, according to scientists like Dr. Robin Carhart-Harris of UCSF and Professor David Nutt of Imperial College London, may be to allow us to cope with adversity and stress. They hypothesize that there are two distinct subsystems of the serotonin (also known as 5-hydroxytryptamine or 5-HT) system in the brain, defined by their predominant receptor subtypes, 5-HT1A and 5-HT2A. This video aims to explain that hypothesis. What do you think of Sense of Mind’s new style (more visuals, shorter videos)? Let me know in the comments. The neuroscience of serotonin is complex. That’s why I’ve created a playlist on the neurobiology of the serotonin system. Link to the rest of the serotonin videos:   • Serotonin Miniseries   Chapters: 00:00 Whenever you experience stress or adversity, you can either cope passively or actively. 00:16 The Carhart-Harris and Nutt Adversity hypothesis of serotonin’s function in the brain 00:54 This is the final installment in a playlist about serotonin 02:03 Part 1: The neural circuitry of anxiety and stress 03:45 Part 2: The role of 5-HT1AR in passive coping 04:25 Why we don’t freak out every time something irritating happens (1A predominance) 04:53 How the 1A receptor calms down the neural stress circuitry 06:05: Important caveat: THIS IS VERY MESSY 06:57 Part 3: The role of 5-HT2AR in active coping 07:10 The cortex is very important in active coping 07:46 The 2A receptor is highly expressed in the cortex and important in brain plasticity 08:23 Psychedelic drugs like LSD and psilocybin bind to 2A 08:58 Psilocybin can alleviate treatment-resistant major depression 11:10 2A binds serotonin more weakly than 1A 11:25 Please sign up for the video newsletter and podcast! 12:01 Part 3: The bipartite model of serotonin brain function (Carhart-Harris and Nutt Adversity hypothesis) 12:29 Need an intro to synaptic transmission? 12:56 Summary 13:58 REMEMBER: This is a hypothesis, not a Theory. 14:30 Check out all my serotonin videos! – Sign up for the weekly video newsletter (free!): http://senseofmindshow.com/newsletter/ Subscribe to the podcast (new episode every week!): https://anchor.fm/senseofmind Instagram:   / sense.ofmind   Facebook:   / senseofmindshow   – Sources Cited: Pollan, M. (2019). How to change your mind: What the new science of psychedelics teaches us about consciousness, dying, addiction, depression, and transcendence. Penguin Books. https://michaelpollan.com/books/how-t... Sharp, T., & Barnes, N. M. (2020). Central 5-HT receptors and their function; present and future. Neuropharmacology, 177, 108155. https://pubmed.ncbi.nlm.nih.gov/32522... Dingman M. Know Your Brain: Raphe Nuclei. Neuroscientifically Challenged. https://neuroscientificallychallenged.... Published October 27, 2017. Di Giovanni, G., & De Deurwaerdère, P. (2020). Serotonin research: Crossing scales and boundaries. https://doi.org/10.1016/j.neuropharm.... Hoyer, D. (2020). Targeting the 5-HT system: Potential side effects. Neuropharmacology, 108233. https://pubmed.ncbi.nlm.nih.gov/32805... Mosienko, V., Bader, M., & Alenina, N. (2020). The serotonin-free brain: behavioral consequences of Tph2 deficiency in animal models. In Handbook of Behavioral Neuroscience (Vol. 31, pp. 601-607). Elsevier. https://doi.org/10.1016/B978-0-444-64... Carhart-Harris, R. L., & Nutt, D. J. (2017). Serotonin and brain function: a tale of two receptors. Journal of Psychopharmacology, 31(9), 1091-1120. https://pubmed.ncbi.nlm.nih.gov/28858... Bacqué-Cazenave, J., Bharatiya, R., Barrière, G., Delbecque, J. P., Bouguiyoud, N., Di Giovanni, G., ... & De Deurwaerdère, P. (2020). Serotonin in animal cognition and behavior. International journal of molecular sciences, 21(5), 1649. https://pubmed.ncbi.nlm.nih.gov/32121... Carvajal-Oliveros, A., & Campusano, J. M. (2021). Studying the Contribution of Serotonin to Neurodevelopmental Disorders. Can This Fly?. Frontiers in Behavioral Neuroscience, 14, 262. https://www.frontiersin.org/articles/... JJ Medicine. “Serotonin and Melatonin Synthesis | Tryptophan Metabolism”    • Serotonin and Melatonin Synthesis | T...  . #brainhealth #serotonin #serotoninfunction