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BIH Lecture 32: Gordon Guyatt

In the BIH Lecture on December 1, 2023, Gordon Guyatt talked about the topic “How to Avoid Being Mislead by the Medical Literature”. Dr. Gordon Guyatt is a distinguished Professor in the Department of Health Research Methods, Evidence and Impact, and the Department of Medicine at McMaster University. He is a general internist who has been heavily involved in clinical research. He has published over 1,500 papers in peer-reviewed journals; according to the Web of Science his work has been cited over 195,000 times. In this BIH Lecture Gordon Guyatt will talk about the potentially misleading findings and interpretation of findings in the medical literature. First, He presented evidence that funding of research influences the conclusions that authors draw from their data and suggest that clinicians should never read authors’ discussion of their own work but rather look to systematic reviews or guidelines from unconflicted sources. Second, he presented the problems with surrogate outcomes, and how clinicians must wait for trials that demonstrate benefits on patient-important outcomes before prescribing new treatments. Finally, he showed how randomized trials stopped early for benefit overestimate treatment effects, sometimes to a very large degree. The lecture was moderated by Ulrich Dirnagl (Head of BIH Quest Center). About the Speaker: https://www.einsteinfoundation.de/en/... Further information on the BIH Lecture Series "Frontiers in Translational Medicine - Scientific and Structural Challenges": https://www.bihealth.org/de/aktuelles...