Скачать с ютуб Paper breakdown: Could NLRP3 inhibitors be therapeutic in Alzheimer's disease? (2) в хорошем качестве

Paper breakdown: Could NLRP3 inhibitors be therapeutic in Alzheimer's disease? (2)

In these videos were we're diving into this paper: Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models. Daniels MJD, Rivers-Auty J, .... Lawrence CB, Brough D, https://pubmed.ncbi.nlm.nih.gov/27509... Learning objectives: Understand the experimental techniques used by Daniels et al. to investigate the potential mechanisms of action of NLRP3 inhibiting NSAIDs. Explain how the data obtained by Daniels et al. supports the hypothesis that the NLRP3 inhibiting effect of certain NSAIDs is linked to their ability to inhibit VRAC channels. Understand the difference between reversible and irreversible inhibitors and how Daniels et al. used this concept to investigate the mechanism of action of NSAIDs. Gain an understanding of the role of ion flux in NLRP3 inflammasome activation and how the NLRP3 inhibiting effect of certain NSAIDs can be explained by their impact on ion flux.