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Aldactone

For more information about Aldactone & to test your knowledge, click here: http://empowern.com/2015/07/aldactone/ ‎ Spironolactone is a type of potassium-sparing diuretic also known as a water pill. It is sold under the brand name of Aldactone. Spironolactone is a particular pharmacologic antagonist of aldosterone. The word Antagonist in medical terms means - a substance that blocks an action and aldosterone is a steroidal hormone which is produced by the adrenal cortex. One of the greatest benefits of using this diuretic is that it prevents the blood potassium levels from dropping too low as it stops the body from absorbing too much salt. So it has a dual purpose by being an effective antihypertensive drug, and also is effective for the treatment of edema, which might happen in a nephrotic syndrome, cirrhosis of the liver and congestive heart failure. Mechanism of action: Blood pressure depends on the level of water and salt in the bloodstream, and kidneys have the capacity to hold salt and water. The adrenal cortex releases a steroid hormone or mineralocorticoid known as aldosterone, which plays an important role in regulating blood pressure. It causes the kidneys to reabsorb sodium and water and discharge potassium, this increases blood pressure. But sometimes when the mechanism becomes dysfunctional, it causes aldosterone to behave pathogenically and increases the risks of kidney and cardiovascular diseases which is more serious in those persons who are already at risk. Spironolactone reverses the action of aldosterone and causes the kidneys to preserve potassium while discharging sodium and water through the urine. It does so by attaching to the aldosterone receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted tubule of the kidney. Therefore, spironolactone is considered to be a potassium-sparing diuretic as it increases urine output while retaining potassium. When there is lower water volume in the blood, blood pressure decreases. Which explains why in hypertension, the level of water in the bloodstream is high. As a diuretic, spironolactone is not very effective if used alone, as it only affects the collecting tubules where only a low level of sodium is retained. For better results, it can be used with other diuretics. You will see (Aldactone) used to treat several conditions: It may be prescribed to the hypertensive patients as an anti-hypertensive and diuretic. It is mainly used to treat congestive heart failure and edema that occurs in patients with cirrhosis of the liver and nephrotic syndrome. It is also used to treat hypokalemia, and basic hyperaldosteronism.