Скачать с ютуб INFLAMMATION Part 3: Leukocyte Activation - PHAGOCYTOSIS в хорошем качестве

INFLAMMATION Part 3: Leukocyte Activation - PHAGOCYTOSIS

In this short tutorial i have described the the basics of process of leukocyte activation and described PHAGOCYTOSIS in detail.. Visit http://ilovepathology.com/ for more topics in Pathology! ***Follow me**** Twitter :   / vijaypatho     / ilovepathology2   Facebook:   / ilovepathology   What NEXT? After recruitment of leukocytes To recognize the microbes/necrotic cells/foreign bodies Activation of Leukocytes Phagocytosis & intracellular Killing What NEXT? After recruitment of leukocytes To recognize the microbes/necrotic cells/foreign bodies Activation of Leukocytes Phagocytosis & Killing How these stimuli are recognized by the PHAGOCYTES? PHAGOCYTIC RECEPTORS Mannose receptors Bind terminal mannose & fucose residues of glycoproteins & GlycolipidsThese sugars are found in walls of microbesNot found in mammalian cells Scavenger receptors Bind modified LDL particles Opsonin receptors Recognize opsonins Opsonin: antibody that renders bacteria and other cells susceptible to phagocytosis, IgG, C3b, Mannose binding lectin What happens when leukocytes are activated? Phagocytosis Destruction of Phagocytosed Microbes & dead cells;By Reactive oxygen & nitrogen species& lysosomal enzymes Destruction of extracellular microbes & dead cells;By forming extracellular “traps” Production of chemical mediators;Amplify inflammation Phagocytosis A process Which involves the recognition , engulfment and digestion of Microbes, dead cells an foreign bodies Greek word Phagein, meaning "to devour" kytos, meaning "cell", and -osis, meaning "process") Also referred to as “cell eating” kILLING: Occur in neutrophils and Macrophages By Reactive oxygen species Reactive nitrogen species Lysosomal enzymes The killing occur in phagolysosomes thus avoiding damage to cell’s cytoplasm and nucleus REACTIVE OXYGEN SPECIES Produced by NADPH Oxidase (Phagocyte oxidase) Phagocyte oxidase is present in the membrane of phagosome and lysosome Thus ROS, can be produced in lysosome and Phagolysosome