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INFLAMMATION Part 2: Cellular Events- Leukocyte Recruitment.

In this short tutorial i have described the the basic concepts of inflammation and described cellular events in inflammation.. Visit http://ilovepathology.com/ for more topics in Pathology! ***Follow me**** Twitter :   / vijaypatho     / ilovepathology2   Facebook:   / ilovepathology   Cellular events in Inflammation Recruitment of Leukocytes In the lumen Magination , rolling, Adhesion Across the vessel wall Outside the vessel wall Chemotaxis Cellular events in Inflammation The influx of the leukocytes ( neutrophils & Monocytes) to the site of injury These leukocytes ingest and destroy the injurious agents ( microbes/necrotic tissue/foreign bodies) [PHAGOCYTOSIS] Also these leukocytes secrete growth factors needed for repair. How does leukocytes travel from vessel lumen to the site of injury?? Multistep process Mediated and controlled by ADHESION MOLECULES and CHEMOKINES Why neutrophils predominate early ?? They are more in number Respond more rapidly to chemokines than others Attach more firmly to adhesion molecules BUT, They are short lived!! Undergo apoptosis and disappear in 24-48 hrs Replaced by monocytes, as they survive longer and can proliferate in tissues Exceptions Pseudomonas infections : neutrophils continues to be recruited for several days Viral infections: lymphocytes predominate Allergic infections: eosinophils predominate What is the therapeutic implication of understanding this whole process?? Helped in finding the therapeutic targets for controlling harmful inflammation Eg: TNF blockers Integrin antagonists: Approved.. And in clinical trials. What NEXT? After recruitment of leukocytes To recognize the microbes/necrotic cells/foreign bodies Activation of Leukocytes Phagocytosis & intracellular Killing